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selective mtor inhibitors  (Aeovian Pharmaceuticals)

 
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    Aeovian Pharmaceuticals selective mtor inhibitors
    Selective Mtor Inhibitors, supplied by Aeovian Pharmaceuticals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/selective+mtor+inhibitors/inhibitors+mtor+selective/pm42126807-268-23-16
    Average 86 stars, based on 1 article reviews
    selective mtor inhibitors - by Bioz Stars, 2026-10
    86/100 stars

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    other:

    Article Title: Sleeve gastrectomy improves metabolic health, cognition, and Alzheimer’s Disease pathology in 3xTG mice
    Article Snippet: D.W.L. has received funding from, and is a scientific advisory board member of, Aeovian Pharmaceuticals, which seeks to develop novel, selective mTOR inhibitors for the treatment of various diseases.

    Article Title: Bench to bedside: is rapamycin headed for the docTOR?
    Article Snippet: Conflict of interest DWL has received funding from, and is a scientific advisory board member of, Aeovian Pharmaceuticals, which seeks to develop novel, selective mTOR inhibitors for the treatment of various diseases.



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    Fig. 7. 5-HT7R promotes CCR5 ubiquitination via mTOR. (A) mTOR inhibitor reverses 5-HT7R mediated suppression on CCR5. RAW264.7, PC12, and BV-2 cells were stimulated with 5-HT7R agonist (LP-211) and /or mTOR inhibitor (AY-22989) for 12 hr. Then cells were lysed and the expressions of CCR5 were analyzed using immunoblotting. (B&C) mTOR inhibitor reverses 5-HT7R and STUB1 induced CCR5 ubiquitination in HEK 293 T cells. Cells were transfected with plasmids encoding Flag-CCR5, HA-Ub-K48, (B) V5-5-HT7R or (C) V5-STUB1 for 48 hr, treated with MG132 (20 lg/mL) for 6 hr, and with or without AY-22989 (10 lM) for 12 hr, immunoprecipitated with Flag antibody, and then detected by western blot for the indicated antibodies. Three independent experiments were conducted for all panels.

    Journal: Journal of advanced research

    Article Title: 5-HT 7 R enhances neuroimmune resilience and alleviates meningitis by promoting CCR5 ubiquitination.

    doi: 10.1016/j.jare.2024.02.017

    Figure Lengend Snippet: Fig. 7. 5-HT7R promotes CCR5 ubiquitination via mTOR. (A) mTOR inhibitor reverses 5-HT7R mediated suppression on CCR5. RAW264.7, PC12, and BV-2 cells were stimulated with 5-HT7R agonist (LP-211) and /or mTOR inhibitor (AY-22989) for 12 hr. Then cells were lysed and the expressions of CCR5 were analyzed using immunoblotting. (B&C) mTOR inhibitor reverses 5-HT7R and STUB1 induced CCR5 ubiquitination in HEK 293 T cells. Cells were transfected with plasmids encoding Flag-CCR5, HA-Ub-K48, (B) V5-5-HT7R or (C) V5-STUB1 for 48 hr, treated with MG132 (20 lg/mL) for 6 hr, and with or without AY-22989 (10 lM) for 12 hr, immunoprecipitated with Flag antibody, and then detected by western blot for the indicated antibodies. Three independent experiments were conducted for all panels.

    Article Snippet: Asenapine maleate (AM, S1283) a 5-HT multi-receptor antagonist, SB269970 (S2849) a 5-HT7R selective antagonist, and Rapamycin (AY-22989, S1039) a selective mTOR inhibitor purchased from Selleck (USA).

    Techniques: Ubiquitin Proteomics, Western Blot, Transfection, Immunoprecipitation

    Fig. 9. Schematic diagram of how the FLX/5-HT7R axis promotes neuroimmune resilience and prevents meningitis. A) Left panel: S.P meningitis induces uncontrolled activation of microglia and macrophage, which leads to cytokine storm, neurotoxicity, and cognitive decline. Right panel: FLX administration or positive mental status up- regulates 5-HT, which promotes the resilience of the microglia, macrophage, and neuron, finally resulting in meningitis protection. B) Mechanisms by which the FLX/5-HT7R axis inhibits CCR5 and promotes neuroimmune resilience. FLX promotes CCR5 degradation via 5-HT7R. 5-HT7R signaling recruits the E3 ligase STUB1 via mTOR and then initiated the ubiquitination and degradation of CCR5 at Lys138 and Lys322. The degradation of CCR5 by 5-HT7R blocked S.P meningitis induced excessive activation of microglia and macrophage and inhibited MAPK/CREB mediated neurotoxicity and cognitive decline, finally leading to neuroimmune resilience.

    Journal: Journal of advanced research

    Article Title: 5-HT 7 R enhances neuroimmune resilience and alleviates meningitis by promoting CCR5 ubiquitination.

    doi: 10.1016/j.jare.2024.02.017

    Figure Lengend Snippet: Fig. 9. Schematic diagram of how the FLX/5-HT7R axis promotes neuroimmune resilience and prevents meningitis. A) Left panel: S.P meningitis induces uncontrolled activation of microglia and macrophage, which leads to cytokine storm, neurotoxicity, and cognitive decline. Right panel: FLX administration or positive mental status up- regulates 5-HT, which promotes the resilience of the microglia, macrophage, and neuron, finally resulting in meningitis protection. B) Mechanisms by which the FLX/5-HT7R axis inhibits CCR5 and promotes neuroimmune resilience. FLX promotes CCR5 degradation via 5-HT7R. 5-HT7R signaling recruits the E3 ligase STUB1 via mTOR and then initiated the ubiquitination and degradation of CCR5 at Lys138 and Lys322. The degradation of CCR5 by 5-HT7R blocked S.P meningitis induced excessive activation of microglia and macrophage and inhibited MAPK/CREB mediated neurotoxicity and cognitive decline, finally leading to neuroimmune resilience.

    Article Snippet: Asenapine maleate (AM, S1283) a 5-HT multi-receptor antagonist, SB269970 (S2849) a 5-HT7R selective antagonist, and Rapamycin (AY-22989, S1039) a selective mTOR inhibitor purchased from Selleck (USA).

    Techniques: Activation Assay, Ubiquitin Proteomics